Makzit

Makzit® 500 tablet: Each film-coated tablet contains Azithromycin Dihydrate USP equivalent to Azithromycin 500 mg.

Makzit® 15 ml PFS: When reconstituted, each 5 ml suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.

Makzit® 30 ml PFS: When reconstituted, each 5 ml suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.

Makzit® contains Azithromycin USP. It is an azalide antibiotic. Azithromycin acts by binding to the 50s ribosomal subunit of susceptible organisms, thus interfering with microbial protein synthesis.

Azithromycin is well tolerated with a low incidence of side effects. Most frequently reported side effects are related to Gastrointestinal system with diarrhoea, nausea, abdominal pain, flatulence, melena. Allergic reactions such as rash, edema, urticaria have occured and there have also been rare reports of  serious hypersensitivity reactions. Transient mild reductions in neutrophil counts have occasionally been observed in clinical trials, although a causal relationship to Azithromycin has not been established.

Liver is the principle route of elimination of Azithromycin, caution should be exercised when Azithromycin is administered to patients with impaired hepatic function. If any allergic reaction occurs, the drug should be discontinued and appropriate therapy should be instituted.

Azithromycin absorption was reduced in presence of food & antacid. So, Azithromycin should be administered 1 hour before or 2 hour after taking food & antacid. Careful monitoring of patients is advised if Azithromycin is concurrently used with digoxin & ergot derivatives, as there is possibility of increased concentration of digoxin and theoretical possibility of ergotism. There have been no pharmacokinetic drug interactions between Azithromycin and warfarin, theophylline, carbamazepine, methylprednisolone and cimetidine.

Most adverse events experienced in higher then recommended doses were similar in type and may be more frequent than those seen at normal doses. The incidence of tinnitus and ototoxicity is more frequent in overdosage than at normal doses. In the event of overdosage, general symptomatic and supportive measures are indicated as required.

Store in a cool and dry place below 30º C. Protect from light and moisture.

Makzit® 500 Tablet: Each box containing 3X4’s tablet in Alu-Alu blister strips.

Makzit® 15 ml PFS: When reconstituted bottle contains 15 ml suspension.

Makzit® 30 ml PFS: When reconstituted bottle contains 30 ml suspension.