Doctil

Doctil® 250 mg tablet: Each film-coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 250 mg.

Doctil® 500 mg tablet: Each film-coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 500 mg.

Doctil® (Cefuroxime) is a 2nd generation Cephalosporin antibiotic active against a wide range of gram-positive and gram-negative organisms including many beta-lactamase producing strains. It is indicated for the treatment of infections caused by sensitive bacteria.

Cefuroxime is indicated in-

■ Pharyngitis

■ Tonsillitis

■ Acute bacterial otitis media

■ Acute bacterial maxillary sinusitis

■ Lower repiratory tract infections including pneumonia

■ Acute bacterial exacerbation of chronic bronchitis &

secondary bacterial infections of acute bronchitis

■ Skin & skin structure infections

■ Urinary tract infection

■ Bone and joint infection

■ Uncomplicated & disseminated gonococcal infections

■ Septicemia

■ Meningitis and

■ Surgical Prophylaxis.

Generally Cefuroxime is well tolerated, However few side effects like nausea, vomiting, diarrhoea, abdominal discomfort or pain may occur. Besides these rarely (0.2%)renal dysfunction, anaphylaxis, angioedema, pruritus, rash, serum sickness and urticaria have been reported.

Prolonged administration of Cefuroxime may result in evergrowth of non-susceptible micro-organisms. If superinfection occurs during therapy, appropriate measures should be taken. Cefuroxime should be given with caution to patients receiving concurrent treatment with potent diuretics because these diuretics are suspected of adversely affecting renal function.

Concomitant administration of probenecid with Cefuroxime Axetil increases the area under the serum concentration versus time curve by 50%. Drugs that reduce gastric acidity may result in a lower bioavailability of Cefuroxime Axetil compared with that of fasting state and tend to cancel the effect of postprandial absorption.

Overdose of Cephalosporins can cause cerebral irritation leading to convulsions. Serum levels of Cefuroxime can be reduced by hemodialysis and peritoneal dialysis.

Store in a cool and dry place, protected from light.

Doctil® 250 mg Tablet:

Each box contains 2X10's tablets in Alu-Alu blister strips.

Doctil® 500 mg Tablet:

Each box contains 2X10's tablets in Alu-Alu blister strips.